Carabao Cup giantkillers Grimsby have another chance to cause an upset after being drawn at home to Keith Andrews' Brentford in the fourth round.
The only remaining League Two side have already dispatched Manchester United at home and Championship strugglers Sheffield Wednesday away and their reward is another Premier League opponent at home to the west London side managed by former Republic of Ireland assistant and player Andrews.
Holders Newcastle host Tottenham, who also ended a long wait for a trophy last season with success in the Europa League, in one of four all top-flight ties.
The others are Liverpool at home to Crystal Palace, Arsenal v Brighton and Wolves hosting Chelsea.
Championship side Swansea, the 2013 winners, host Manchester City while the other two Welsh teams left in the competition - Wrexham and Cardiff - face each other.
League One Wycombe also have the chance of creating an upset as they host Fulham.
Fourth round draw
Arsenal v Brighton
Grimsby Town v Brentford
Swansea City v Manchester City
Newcastle United v Tottenham Hotspur
Wrexham v Cardiff City
Liverpool v Crystal Palace
Wolverhampton Wanderers v Chelsea
Wycombe Wanderers v Fulham
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