The Department of Health has been notified of six further deaths associated with Covid-19.
456 new cases of the virus have also been reported.
Of the deaths reported today, all occurred in November. It brings the total number of deaths in Ireland to 1,978.
There have now been 67,526 confirmed cases of Covid-19 in Ireland since the start of the pandemic.
As of 2pm today, 254 Covid-19 patients are hospitalised, of which 32 are in ICU.
There were 11 additional hospitalisations in the past 24 hours.
Of the cases notified today, 210 are men and 246 are women. 69% are under 45 years of age, with the median age being 33 years old.
151 of today's cases are in Dublin, 38 in Limerick, 27 in Cork, 27 in Donegal, 27 in Galway, and the remaining 186 cases are spread across 20 other counties.
"Analysis of today's data shows the 5-day moving average of case numbers has increased from 354 to 392," said Chief Medical Officer Dr Tony Holohan.
"We have seen higher numbers in recent days than we expected based on the encouraging trends of the last three weeks. We are concerned that this progress is at risk.
"We have to remember that the virus is still very active in the community and we cannot let our guard slip. NPHET will continue to monitor the situation closely over the coming days," he added.
"We all need to focus on what we can do to stop the spread of this disease; wash our hands regularly, wear a face covering, keep our distance from others, avoid crowds, limit our social network, know the symptoms, self-isolate and contact a GP if we have them. Stay at home and restrict our movements if you are a close contact of a confirmed case."
Professor Philip Nolan has said Ireland would be facing 150 Covid-19 related deaths a month and "at least" 1,200 people in hospital had the country remained at Level 3 restrictions.
The chair of the National Public Health Emergency Team's Epidemiological Modelling Advisory Group was responding to an article in the Irish Times.
Writing on Twitter, he said to have "kept things simmering along at Level 3" (with 1,000 cases a day) would have resulted in "at least 1,200 hospitalisations and 150 deaths a month".
He added: "Things kept simmering tend to boil over."
The number of deaths related to the virus notified so far this month is now 62 after seven more deaths were announced yesterday.
The Chief Medical Officer, Dr Tony Holohan, has urged people not to drop their guard against the spread of the disease.
"If we can keep up high levels of compliance, we can get to where we need to be on 1 December," he said.
Taoiseach Micheál Martin said yesterday that the Government will take advice from the National Public Health Emergency Team but the "Government will take the decision on how we exit Level 5".
In Northern Ireland, a further 10 people have died with Covid-19 - eight in the past 24 hours - bringing the death toll there to 846.
There were also 511 new cases of the disease reported. The total number of confirmed cases there is now 46,359.
There are 422 coronavirus patients in Northern Irish hospitals, with 49 in ICU, 39 of whom are on ventilators.
Additional reporting: Vincent Kearney
